COVID-19 CLINICAL STUDY FROM CHINA PUBLISHED FEBRUARY 2020 IN LANCET MEDICAL JOURNAL
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
By:Chen, NS (Chen, Nanshan)[ 1 ] ; Zhou, M (Zhou, Min)[ 5,6 ] ; Dong, X (Dong, Xuan)[ 1 ] ; Qu, JM (Qu, Jieming)[ 5,6 ] ; Gong, FY (Gong, Fengyun)[ 2 ] ; Han, Y (Han, Yang)[ 3,10 ] ; Qiu, Y (Qiu, Yang)[ 10 ] ; Wang, JL (Wang, Jingli)[ 2 ] ; Liu, Y (Liu, Ying)[ 4 ] ; Wei, Y (Wei, Yuan)[ 1 ] …More
LANCET
Volume: 395
Issue: 10223
Pages: 507-513
DOI: 10.1016/S0140-6736(20)30211-7
Published: FEB 15 2020
Document Type:Article
Abstract
Background
In December, 2019, a pneumonia associated with the 2019 novel coronavirus
(2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the
epidemiological and clinical characteristics of 2019-nCoV pneumonia.
Methods In this retrospective, single-centre study, we included all confirmed
cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020.
Cases were confirmed by real-time RT-PCR and were analysed for epidemiological,
demographic, clinical, and radiological features and laboratory data. Outcomes
were followed up until Jan 25, 2020.
Findings Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of
exposure to the Huanan seafood market. The average age of the patients was 55.5
years (SD 13.1), including 67 men and 32 women. 2019-nCoV was detected in all
patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients
had clinical manifestations of fever (82 [83%] patients), cough (81 [82%]
patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%]
patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore
throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two
[2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one
[1%] patient). According to imaging examination, 74 (75%) patients showed
bilateral pneumonia, 14 (14%) patients showed multiple mottling and
ground-glass opacity, and one (1%) patient had pneu-mothorax. 17 (17%) patients
developed acute respiratory distress syndrome and, among them, 11 (11%)
patients worsened in a short period of time and died of multiple organ failure.
Interpretation The 2019-nCoV infection was of clustering onset, is more likely
to affect older males with comorbidities, and can result in severe and even
fatal respiratory diseases such as acute respiratory distress syndrome. In
general, characteristics of patients who died were in line with the MuLBSTA
score, an early warning model for predicting mortality in viral pneumonia.
Further investigation is needed to explore the applicability of the MuLBSTA
score in predicting the risk of mortality in 2019-nCoV infection. Copyright (C)
2020 Elsevier Ltd. All rights reserved.
Keywords
KeyWords Plus:RESPIRATORY SYNDROME CORONAVIRUS; MERS; OUTBREAK; SARS; COV
Author Information
Reprint Address: Zhang, L (reprint author)
| Wuhan Jinyintan Hosp, TB & Resp Dept, Wuhan 430023, Peoples R China. |
Reprint Address: Zhang, XX (reprint author)
| Shanghai Jiao Tong Univ, Sch Med, Res Lab Clin Virol, Ruijin Hosp, Shanghai 200025, Peoples R China. |
Reprint Address: Zhang, XX (reprint author)
Addresses:
E-mail Addresses:[email protected]; [email protected]
Funding
| Funding Agency | Grant Number |
| National Key R&D Program of China | 2017YFC1309700 |
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