COVID-19 CLINICAL STUDY FROM CHINA PUBLISHED FEBRUARY 2020 IN LANCET MEDICAL JOURNAL

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

By:Chen, NS (Chen, Nanshan)^[ 1 ] ; Zhou, M (Zhou, Min)^[ 5,6 ] ; Dong, X (Dong, Xuan)^[ 1 ] ; Qu, JM (Qu, Jieming)^[ 5,6 ] ; Gong, FY (Gong, Fengyun)^[ 2 ] ; Han, Y (Han, Yang)^[ 3,10 ] ; Qiu, Y (Qiu, Yang)^[ 10 ] ; Wang, JL (Wang, Jingli)^[ 2 ] ; Liu, Y (Liu, Ying)^[ 4 ] ; Wei, Y (Wei, Yuan)^[ 1 ] …More

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LANCET

Volume: 395

 Issue: 10223

 Pages: 507-513

DOI: 10.1016/S0140-6736(20)30211-7

Published: FEB 15 2020

Document Type:Article

Abstract

Background In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia.

Methods In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020.

Findings Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55.5 years (SD 13.1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). According to imaging examination, 74 (75%) patients showed bilateral pneumonia, 14 (14%) patients showed multiple mottling and ground-glass opacity, and one (1%) patient had pneu-mothorax. 17 (17%) patients developed acute respiratory distress syndrome and, among them, 11 (11%) patients worsened in a short period of time and died of multiple organ failure.

Interpretation The 2019-nCoV infection was of clustering onset, is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In general, characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia. Further investigation is needed to explore the applicability of the MuLBSTA score in predicting the risk of mortality in 2019-nCoV infection. Copyright (C) 2020 Elsevier Ltd. All rights reserved.

Keywords

KeyWords Plus:RESPIRATORY SYNDROME CORONAVIRUS; MERS; OUTBREAK; SARS; COV

Author Information

Reprint Address: Zhang, L (reprint author)

Wuhan Jinyintan Hosp, TB & Resp Dept, Wuhan 430023, Peoples R China.

Reprint Address: Zhang, XX (reprint author)

Shanghai Jiao Tong Univ, Sch Med, Res Lab Clin Virol, Ruijin Hosp, Shanghai 200025, Peoples R China.

Reprint Address: Zhang, XX (reprint author)

Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp North, Shanghai 200025, Peoples R China.

Addresses:

	[ 1 ] Wuhan Jinyintan Hosp, TB & Resp Dept, Wuhan 430023, Peoples R China
	[ 2 ] Wuhan Jinyintan Hosp, Infect Dis Dept, Wuhan, Peoples R China
	[ 3 ] Wuhan Jinyintan Hosp, Sci & Educ Dept, Wuhan, Peoples R China
	[ 4 ] Wuhan Jinyintan Hosp, Off Drug Clin Trial Inst, Wuhan, Peoples R China
	[ 5 ] Shanghai Jiao Tong Univ, Sch Med, Dept Resp & Crit Care Med, Ruijin Hosp, Shanghai, Peoples R China
	[ 6 ] Shanghai Jiao Tong Univ, Sch Med, Inst Resp Dis, Shanghai, Peoples R China
	[ 7 ] Shanghai Jiao Tong Univ, Sch Med, Res Lab Clin Virol, Ruijin Hosp, Shanghai 200025, Peoples R China
	[ 8 ] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp North, Shanghai 200025, Peoples R China
	[ 9 ] Shanghai Jiao Tong Univ, Sch Med, Clin Res Ctr, Ruijin Hosp North, Shanghai, Peoples R China
	[ 10 ] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan, Peoples R China

E-mail Addresses:zhangx@shsmu.edu.cn; zhangli080806@163.com

Funding

Funding Agency	Grant Number
National Key R&D Program of China	2017YFC1309700